Pregabalin gắn với one tiểu đơn vị phụ (α2 - δ protein) của kênh calci cổng điện thế trong hệ thống thần kinh trung ương.
Swelling of your arms, legs and ft. This swelling can be quite a major problem for people with coronary heart challenges.
Pregabalin is usually utilized for epilepsy, but You can even just take it to help with ache or stress if you do not have epilepsy.
Breathing Problems. Pregabalin could potentially cause gradual or shallow breathing, particularly when you will be using another drugs that can result in slowed breathing, including the opioid medicines codeine or oxycodone, or if you already have breathing complications.
There are actually postmarketing reports of everyday living-threatening or deadly respiratory despair in patients getting LYRICA with opioids or other CNS depressants, or in the placing of fundamental respiratory impairment.
Pregabalin is effectively absorbed following oral administration, is removed mostly by renal excretion, and it has an elimination 50 percent-lifetime of about 6 several hours.
In the event your pharmacist is unable to provide you with the complete volume prescribed, You will need to go back to get your remaining drugs in 28 times of receiving your prescription.
Sự an toàn và Helloệu quả của pregabalin cho trẻ em dưới twelve tuổi và thiếu niên chưa được thiết lập.
swollen hands, arms, legs and ft – In case your ft are swollen, attempt sitting down together with your ft up with a chair or bed and check out not to face for years. Exercise may possibly help When your arms are swollen. If that doesn't assist or it will become painful, Speak to your doctor.
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Dùng đồng thời pregabalin với các thuốc tránh thai đường uống norethisteron và/hoặc ethinyl estradiol không ảnh hưởng đến sự ổn định về dược động học của cả two thuốc. Pregabalin có thể ảnh hưởng tới tác dụng của ethanol và lorazepam.
(As an example: A affected individual initiating LYRICA therapy for postherpetic neuralgia with normal renal function (CLcr better than or get more info equal to 60 mL/min), receives a complete every day dose of 150 mg/day pregabalin.
Seizures and coronary heart block have also been noted. Deaths are claimed inside the placing of lone LYRICA overdose and together with other CNS depressants.